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    CNKI为你找到相关结果

    Transformative hyaluronic acid-based active targeting ...  CNKI文献

    Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE...

    Lu Zhong Lu Xu... 《Acta Pharmaceutica Sinica B》 2019年02期 期刊

    关键词: Hyaluronic / acid / Benzoic / imine

    下载(16)| 被引(0)

    A novel oral prodrug-targeting transporter MCT 1: 5-fl...  CNKI文献

    Monocarboxylate transporter 1(MCT1) is responsible for oral absorption of short-chain monocarboxylic acids from small intestine, hence, it's likely to serve as an ideal design target for the deve...

    Yixin Sun Dongyang Zhao... 《Asian Journal of Pharmaceutical Sciences》 2019年06期 期刊

    关键词: 5-Fluorouracil / Prodrugs / Monocarboxylate / transporter

    下载(3)| 被引(0)

    Integration of phospholipid-drug complex into self-nan...  CNKI文献

    Self-nanoemulsifying drug delivery system(SNEDDS) has emerged as a promising platform to improve oral absorption of drugs with poor solubility and low permeability. However,large polarity molecules w...

    Dawei Ding Bingjun Sun... 《Asian Journal of Pharmaceutical Sciences》 2019年05期 期刊

    关键词: PTX / PLDC / SNEDDS / PLDC-SNEDDS

    下载(9)| 被引(0)

    Exploring the relationship of hyaluronic acid molecula...  CNKI文献

    Although it is reported that the targeting ability of hyaluronic acid(HA)-based nanoparticles(NPs) is molecular weight(MW) dependent,the influence of HA MW on targeting efficiency of HA-functionalize...

    Lu Zhong Yanying Liu... 《Asian Journal of Pharmaceutical Sciences》 2019年05期 期刊

    关键词: Hyaluronic / acid / Molecular / weight

    下载(7)| 被引(0)

    The studies of PLGA nanoparticles loading atorvastatin...  CNKI文献

    A biodegradable poly(lactic-co-glycolic acid) loading atorvastatin calcium(AC) nanoparticles(AC-PLGA-NPs) were prepared by probe ultrasonication and evaporation method aiming at improving the oral bi...

    Zhenbao Li Wenhui Tao... 《Asian Journal of Pharmaceutical Sciences》 2017年03期 期刊

    关键词: Atorvastatin / calcium / AC-PLGA-NPs / Probe

    下载(17)| 被引(3)

    Insight into the preformed albumin corona on in vitro ...  CNKI文献

    Preformed albumin corona of albumin-nonselective nanoparticles(NPs) is widely exploited to inhibit the unavoidable protein adsorption upon intravenous administration. However,very few studies have co...

    Zhenbao Li Dan Li... 《Asian Journal of Pharmaceutical Sciences》 2019年01期 期刊

    关键词: Preformed / albumin / corona / Albumin-nonselective

    下载(14)| 被引(0)

    Amino functionalized chiral mesoporous silica nanopart...  CNKI文献

    In the present paper, chiral mesoporous silica nano-cocoon(A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin(IMC), a poorly soluble drug, was studie...

    Xin Wang Chang Li... 《Asian Journal of Pharmaceutical Sciences》 2019年04期 期刊

    关键词: Chiral / mesoporous / silica / Amino

    下载(15)| 被引(0)

    Co-amorphous solid dispersion systems of lacidipine-sp...  CNKI文献

    Co-amorphous solid dispersion(C-ASD) systems have attracted great attention to improve the solubility of poorly soluble drugs, but the selection of an appropriate stabilizer to stabilize amorphous fo...

    Zhaomeng Wang Mengchi Sun... 《Asian Journal of Pharmaceutical Sciences》 2019年01期 期刊

    关键词: Co-amorphous / solid / dispersion / Lacidipine

    下载(14)| 被引(0)

    Development and validation of a UPLC–MS/MS assay for ...  CNKI文献

    A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative(2'-deoxy-2', 2'-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl am...

    Gang Wang Dongyang Zhao... 《Asian Journal of Pharmaceutical Sciences》 2017年05期 期刊

    关键词: Gemcitabine / L-carnitine / Prodrug / Pharmacokinetics

    下载(8)| 被引(1)

    Virtual population pharmacokinetic using physiological...  CNKI文献

    The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulation...

    Bin Yang Chunnuan Wu... 《Asian Journal of Pharmaceutical Sciences》 2017年01期 期刊

    关键词: Physiologically / based / pharmacokinetic / model

    下载(10)| 被引(2)

    Polymeric nanoparticles developed by vitamin E-modifie...  CNKI文献

    Oleanolic acid (OA) exhibited good pharmacological activities in the clinical treatment of hypoglycemia, immune regulation, acute jaundice and chronic toxic hepatitis. However, the oral delivery of O...

    Wenjuan Zhang Chufan Liang... 《Asian Journal of Pharmaceutical Sciences》 2017年06期 期刊

    关键词: Oleanolic / acid / Polymeric / nanoparticles

    下载(10)| 被引(0)

    Preparation and stability investigation of tamsulosin ...  CNKI文献

    The objective of this study was to prepare tamsulosin hydrochloride-sustained release(TSH-SR)pellets which showed good release stability with frame-controlled method.TSH was added to Eudragit~?NE30D ...

    Rui Fan Yinghua Sun... 《Asian Journal of Pharmaceutical Sciences》 2017年02期 期刊

    关键词: Eudragit?NE30D / Eudragit?L30D-55 / Release / stability

    下载(17)| 被引(0)

    Optimization, characterization and in vitro/vivo evalu...  CNKI文献

    Azilsartan(AZL), a poorly soluble drug, was considered to be fit for nanocrystals to improve its solubility. Our study intended to prepare AZL nanocrystals by means of bead milling method. Eight stab...

    Jingjing Ma Yinxian Yang... 《Asian Journal of Pharmaceutical Sciences》 2017年04期 期刊

    关键词: Azilsartan / Nanocrystals / Sodium / deoxycholate

    下载(16)| 被引(0)

    Development of Liposome containing sodium deoxycholate...  CNKI文献

    The aim of this study was to enhance oral bioavailability of itraconazole(ITZ) by developing Liposome containing sodium deoxycholate(ITZ-Lip-NaDC). The liposome, consisting of egg yolk lecithin and s...

    Zhenbao Li Meiyu Zhang... 《Asian Journal of Pharmaceutical Sciences》 2017年02期 期刊

    关键词: Itraconazole / ITZ-Lip-NaDC / Dissolution / Intestinal

    下载(9)| 被引(0)

    Current multifunctional albumin-based nanoplatforms fo...  CNKI文献

    Albumin has been widely applied for rational design of drug delivery complexes as natural carriers in cancer therapy due to its distinct advantages of biocompatibility, abundance, low toxicity and ve...

    Chang Li Xin Wang... 《Asian Journal of Pharmaceutical Sciences》 2020年01期 期刊

    关键词: Albumin / Formulations / Multi-mode / therapy

    下载(0)| 被引(0)

    固体分散体的处方筛选和稳定性研究(英文)  CNKI文献

    Solid dispersion is an effective method to improve the solubility and dissolution rate of insoluble drugs.The role of solid dispersion to improve drug dissolution rate is mainly dependent on the prop...

    Chunnuan Wu Jin Sun... 2015年中国药物制剂大会暨中国药学会药剂专业委员会2015年学... 2015-09-26 国际会议

    关键词: solid / dispersions / lacidipine / solvent-shift

    下载(57)| 被引(0)

    Probing the Dipeptide-Based Supramolecular Assembly as...  CNKI文献

    Short peptide-based supramolecular assemblies draw much attention in the field of drug delivery. However, the progress is still limited by inefficient drug loading capacity of the conventional short ...

    孙孟驰 Jin Sun 2018年第十二届中国药物制剂大会论文集 2018-11-30 中国会议

    关键词: short / peptide / supramolecular / assembly

    下载(2)| 被引(0)

    Redox Responsive Prodrug-Nanosystems Self-Assembled by...  CNKI文献

    Malignant tumor has been seriously threatening the human health,and chemotherapy is one of the most commonly used therapeutic strategies.However,the conventional treatments with common anticancer inj...

    罗聪 Jin Sun... 2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学... 2016-11-18 国际会议

    关键词: TPGS / high / PTX / Redox

    下载(5)| 被引(0)

    Redox-Responsive Prodrug Nanoassemblies for Cancer The...  CNKI文献

    Tumor cells are characterized as redox-heterogeneous intracellular microenvironment due to the simultaneous overproduction of reactive oxygen species(ROS) and glutathione(GSH).In our previous study,s...

    Jin Sun Bingju Sun... Proceedings of the 3rd International Conference on Nano... 2018-10-15 国际会议

    关键词: DDS / Redox-Responsive / Prodrug / Nanoassemblies

    下载(0)| 被引(0)

    Carrier-mediated Intestinal Absorption and Enterocytes...  CNKI文献

    Decitabine(DAC),a potent DNA methyltransferase(DNMT) inhibitor,has a limited oral bioavailability.Its5'-amino acid ester prodrugs could lead to a favorable property for oral delivery but the spec...

    Wenhui TAO Dongyang ZHAO... 2017年第十一届中国药物制剂大会暨中国药学会药剂专业委员会... 2017-10-27 国际会议

    关键词: Decitabine / amino / acid / ester

    下载(0)| 被引(0)

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