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    CNKI为你找到相关结果

    Transformative hyaluronic acid-based active targeting ...  CNKI文献

    Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE...

    Lu Zhong Lu Xu... 《Acta Pharmaceutica Sinica B》 2019年02期 期刊

    关键词: Hyaluronic / acid / Benzoic / imine

    下载(16)| 被引(0)

    Redox-sensitive prodrug nanoassemblies based on linole...  CNKI文献

    Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutath...

    Meng Li Liwen Zhao... 《Acta Pharmaceutica Sinica B》 2019年02期 期刊

    关键词: Docetaxel / Nanoassemblies / Mono / thioether

    下载(12)| 被引(0)

    Study on degradation kinetics of epalrestat in aqueous...  CNKI文献

    Drug stability is closely related to drug safety and needs to be considered in the process of drug production,package and storage.To investigate the stability of epalrestat,a carboxylic acid derivati...

    Hong Sun Suyan Liu... 《Journal of Pharmaceutical Analysis》 2019年06期 期刊

    关键词: Epalrestat / RP-HPLC / Degradation / kinetics

    下载(6)| 被引(0)

    Cooperative effect of polyvinylpyrrolidone and HPMC E5...  CNKI文献

    Solid dispersion(SD) systems have been extensively used to increase the dissolution and bioavailability of poorly water-soluble drugs. To circumvent the limitations of polyvinylpyrrolidone(PVP) dispe...

    Zhisu Sun Huicong Zhang... 《Asian Journal of Pharmaceutical Sciences》 2019年06期 期刊

    关键词: Solid / dispersion / Nimodipine / HPMC

    下载(6)| 被引(0)

    A novel oral prodrug-targeting transporter MCT 1: 5-fl...  CNKI文献

    Monocarboxylate transporter 1(MCT1) is responsible for oral absorption of short-chain monocarboxylic acids from small intestine, hence, it's likely to serve as an ideal design target for the deve...

    Yixin Sun Dongyang Zhao... 《Asian Journal of Pharmaceutical Sciences》 2019年06期 期刊

    关键词: 5-Fluorouracil / Prodrugs / Monocarboxylate / transporter

    下载(3)| 被引(0)

    Integration of phospholipid-drug complex into self-nan...  CNKI文献

    Self-nanoemulsifying drug delivery system(SNEDDS) has emerged as a promising platform to improve oral absorption of drugs with poor solubility and low permeability. However,large polarity molecules w...

    Dawei Ding Bingjun Sun... 《Asian Journal of Pharmaceutical Sciences》 2019年05期 期刊

    关键词: PTX / PLDC / SNEDDS / PLDC-SNEDDS

    下载(9)| 被引(0)

    Exploring the relationship of hyaluronic acid molecula...  CNKI文献

    Although it is reported that the targeting ability of hyaluronic acid(HA)-based nanoparticles(NPs) is molecular weight(MW) dependent,the influence of HA MW on targeting efficiency of HA-functionalize...

    Lu Zhong Yanying Liu... 《Asian Journal of Pharmaceutical Sciences》 2019年05期 期刊

    关键词: Hyaluronic / acid / Molecular / weight

    下载(7)| 被引(0)

    Piperacillin enhances the inhibitory effect of tazobac...  CNKI文献

    To assess the mechanism of the pharmacokinetic interaction between piperacillin and tazobactam, renal excretion and pharmacokinetic studies of piperacillin/tazobactam were investigated in normal and ...

    Shilei Yang Zhihao Liu... 《Asian Journal of Pharmaceutical Sciences》 2019年06期 期刊

    关键词: Organic / anion / transporter / Piperacillin

    下载(1)| 被引(0)

    Amino functionalized chiral mesoporous silica nanopart...  CNKI文献

    In the present paper, chiral mesoporous silica nano-cocoon(A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin(IMC), a poorly soluble drug, was studie...

    Xin Wang Chang Li... 《Asian Journal of Pharmaceutical Sciences》 2019年04期 期刊

    关键词: Chiral / mesoporous / silica / Amino

    下载(15)| 被引(0)

    Co-amorphous solid dispersion systems of lacidipine-sp...  CNKI文献

    Co-amorphous solid dispersion(C-ASD) systems have attracted great attention to improve the solubility of poorly soluble drugs, but the selection of an appropriate stabilizer to stabilize amorphous fo...

    Zhaomeng Wang Mengchi Sun... 《Asian Journal of Pharmaceutical Sciences》 2019年01期 期刊

    关键词: Co-amorphous / solid / dispersion / Lacidipine

    下载(14)| 被引(0)

    Effect of raw material variability of glipizide on the...  CNKI文献

    The objective of this study was to understand the impact of active pharmaceutical ingredients(API) particle size on a re-developed generic product of glipizide and to improve its formulation so that ...

    Chenyao Zhao Chan Jin... 《Asian Journal of Pharmaceutical Sciences》 2019年02期 期刊

    关键词: Glipizide / Particle / size / Product

    下载(9)| 被引(0)

    ROS-responsive drug delivery systems for biomedical ap...  CNKI文献

    In the field of biomedicine, stimuli-responsive drug delivery systems(DDSs) have become increasingly popular due to their site-specific release ability in response to a certain physiological stimulus...

    Wenhui Tao Zhonggui He 《Asian Journal of Pharmaceutical Sciences》 2018年02期 期刊

    关键词: Drug / delivery / system / Stimuli-responsive

    下载(23)| 被引(1)

    In vitro/vivo assessment of praziquantel nanocrystals:...  CNKI文献

    To investigate the impact of particle size on in vitro/vivo performance of praziquantel(PZQ), nanocrystals(NCs) and microcrystals(MCs) of PZQ were prepared using the methods of wet milling and jet mi...

    Ruyi Yang Tao Zhang... 《Asian Journal of Pharmaceutical Sciences》 2019年03期 期刊

    关键词: Praziquantel / Nanocrystals / Microcrystals / Dissolution

    下载(3)| 被引(0)

    Preparation and evaluation of duloxetine hydrochloride...  CNKI文献

    The main purpose of the present study was to prepare duloxetine hydrochloride(DXH) entericcoated pellets using different enteric polymers. Three layers(drug-loaded layer, barrier layer,and enteric-co...

    Chen Kuang Yinghua Sun... 《Asian Journal of Pharmaceutical Sciences》 2017年03期 期刊

    关键词: Duloxetine / hydrochloride / Enteric / polymers

    下载(11)| 被引(1)

    Development and validation of a UPLC–MS/MS assay for ...  CNKI文献

    A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative(2'-deoxy-2', 2'-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl am...

    Gang Wang Dongyang Zhao... 《Asian Journal of Pharmaceutical Sciences》 2017年05期 期刊

    关键词: Gemcitabine / L-carnitine / Prodrug / Pharmacokinetics

    下载(8)| 被引(1)

    Virtual population pharmacokinetic using physiological...  CNKI文献

    The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulation...

    Bin Yang Chunnuan Wu... 《Asian Journal of Pharmaceutical Sciences》 2017年01期 期刊

    关键词: Physiologically / based / pharmacokinetic / model

    下载(10)| 被引(2)

    The effect of cephalexin in influencing the pharmacoki...  CNKI文献

    The aim of this study is to investigate the pharmacokinetics of 5′-valyl-cytarabine hydrochloride(OPC) when co-administered with cephalexin, which are both the substrates of PepT 1.The drugs were ad...

    Xiaotong Song Yinghua Sun... 《Asian Journal of Pharmaceutical Sciences》 2017年02期 期刊

    关键词: 5'-Valyl-cytarabine / hydrochloride(OPC) / Cephalexin / Pharmacokinetics

    下载(7)| 被引(2)

    Application of hot melt extrusion to enhance the disso...  CNKI文献

    The aim of this study was to improve the in vitro dissolution rate and oral bioavailability of oleanolic acid(OA), a water insoluble drug belonging to BCS class IV. Hot melt extrusion(HME) was applie...

    Nannan Gao Mengran Guo... 《Asian Journal of Pharmaceutical Sciences》 2017年01期 期刊

    关键词: Hot / melt / extrusion / Solid

    下载(9)| 被引(1)

    Redox Responsive Prodrug-Nanosystems Self-Assembled by...  CNKI文献

    Malignant tumor has been seriously threatening the human health,and chemotherapy is one of the most commonly used therapeutic strategies.However,the conventional treatments with common anticancer inj...

    罗聪 Jin Sun... 2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学... 2016-11-18 国际会议

    关键词: TPGS / high / PTX / Redox

    下载(5)| 被引(0)

    Enhanced oral delivery of paclitaxel using cysteamine ...  CNKI文献

    Currently,the natural barrier of gastrointestinal mucus layer and multi-resistant P-glyprotein(P-gp)are the two major restrictive factors in the oral administration of anticancer drugs.Here,we have d...

    廉鹤 Jin Sun... 2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学... 2016-11-18 国际会议

    关键词: TPGS / oral / Enhanced / oral

    下载(15)| 被引(0)

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