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CNKI为你找到相关结果

Redox-sensitive prodrug nanoassemblies based on linole...  CNKI文献

Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutath...

Meng Li Liwen Zhao... 《Acta Pharmaceutica Sinica B》 2019年02期 期刊

关键词: Docetaxel / Nanoassemblies / Mono / thioether

下载(9)| 被引(0)

Integration of phospholipid-drug complex into self-nan...  CNKI文献

Self-nanoemulsifying drug delivery system(SNEDDS) has emerged as a promising platform to improve oral absorption of drugs with poor solubility and low permeability. However,large polarity molecules w...

Dawei Ding Bingjun Sun... 《Asian Journal of Pharmaceutical Sciences》 2019年05期 期刊

关键词: PTX / PLDC / SNEDDS / PLDC-SNEDDS

下载(9)| 被引(0)

Exploring the relationship of hyaluronic acid molecula...  CNKI文献

Although it is reported that the targeting ability of hyaluronic acid(HA)-based nanoparticles(NPs) is molecular weight(MW) dependent,the influence of HA MW on targeting efficiency of HA-functionalize...

Lu Zhong Yanying Liu... 《Asian Journal of Pharmaceutical Sciences》 2019年05期 期刊

关键词: Hyaluronic / acid / Molecular / weight

下载(5)| 被引(0)

Insight into the preformed albumin corona on in vitro ...  CNKI文献

Preformed albumin corona of albumin-nonselective nanoparticles(NPs) is widely exploited to inhibit the unavoidable protein adsorption upon intravenous administration. However,very few studies have co...

Zhenbao Li Dan Li... 《Asian Journal of Pharmaceutical Sciences》 2019年01期 期刊

关键词: Preformed / albumin / corona / Albumin-nonselective

下载(14)| 被引(0)

Amino functionalized chiral mesoporous silica nanopart...  CNKI文献

In the present paper, chiral mesoporous silica nano-cocoon(A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin(IMC), a poorly soluble drug, was studie...

Xin Wang Chang Li... 《Asian Journal of Pharmaceutical Sciences》 2019年04期 期刊

关键词: Chiral / mesoporous / silica / Amino

下载(5)| 被引(0)

Co-delivery of resveratrol and docetaxel via polymeric...  CNKI文献

Co-delivery of anti-cancer drugs is promising to improve the efficacy of cancer treatment.This study was aiming to investigate the potential of concurrent delivery of resveratrol(RES)and docetaxel(DT...

Xiong Guo Zhiyue Zhao... 《Asian Journal of Pharmaceutical Sciences》 2019年01期 期刊

关键词: Resveratrol / Docetaxel / Methoxyl / poly(ethylene

下载(12)| 被引(0)

Co-amorphous solid dispersion systems of lacidipine-sp...  CNKI文献

Co-amorphous solid dispersion(C-ASD) systems have attracted great attention to improve the solubility of poorly soluble drugs, but the selection of an appropriate stabilizer to stabilize amorphous fo...

Zhaomeng Wang Mengchi Sun... 《Asian Journal of Pharmaceutical Sciences》 2019年01期 期刊

关键词: Co-amorphous / solid / dispersion / Lacidipine

下载(9)| 被引(0)

A donepezil/cyclodextrin complexation orodispersible f...  CNKI文献

The aim of this study was to develop a palatable donepezil(DP) orodispersible film(ODF)to facilitate the swallowing process and investigate the effect of cyclodextrin on tastemasking based on dynamic...

Tingting Liu Xiaocao Wan... 《Asian Journal of Pharmaceutical Sciences》 2019年02期 期刊

关键词: Donepezil / Orodispersible / film / Taste-masking

下载(3)| 被引(0)

ROS-responsive drug delivery systems for biomedical ap...  CNKI文献

In the field of biomedicine, stimuli-responsive drug delivery systems(DDSs) have become increasingly popular due to their site-specific release ability in response to a certain physiological stimulus...

Wenhui Tao Zhonggui He 《Asian Journal of Pharmaceutical Sciences》 2018年02期 期刊

关键词: Drug / delivery / system / Stimuli-responsive

下载(18)| 被引(0)

In vitro/vivo assessment of praziquantel nanocrystals:...  CNKI文献

To investigate the impact of particle size on in vitro/vivo performance of praziquantel(PZQ), nanocrystals(NCs) and microcrystals(MCs) of PZQ were prepared using the methods of wet milling and jet mi...

Ruyi Yang Tao Zhang... 《Asian Journal of Pharmaceutical Sciences》 2019年03期 期刊

关键词: Praziquantel / Nanocrystals / Microcrystals / Dissolution

下载(2)| 被引(0)

Transformative hyaluronic acid-based active targeting ...  CNKI文献

Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE...

Lu Zhong Lu Xu... 《Acta Pharmaceutica Sinica B》 2019年02期 期刊

关键词: Hyaluronic / acid / Benzoic / imine

下载(16)| 被引(0)

A novel mitochondria-targeting tetrapeptide for subcel...  CNKI文献

Mitochondrial dysfunction is associated with the emergence of several neurological and cardiovascular diseases.Hence,mitochondria-targeting delivery strategies are highly significant and critically n...

Yanhui Sun Aiyan Zhan... 《Chinese Chemical Letters》 2019年07期 期刊

关键词: Mitochondrial / targeting / Peptide / SS-31

下载(1)| 被引(0)

Influence of solvent mixtures on HPMCAS-celecoxib micr...  CNKI文献

Hypromellose acetate succinate(HPMCAS) microparticles containing the poorly-water soluble drug celecoxib(CEL) were prepared by electrospraying intended for oral drug delivery. Various solvent mixture...

Adam Bohr Yingya Wang... 《Asian Journal of Pharmaceutical Sciences》 2018年06期 期刊

关键词: Celecoxib / Electrospraying / Hypromellose / acetate

下载(3)| 被引(0)

Probing the Dipeptide-Based Supramolecular Assembly as...  CNKI文献

Short peptide-based supramolecular assemblies draw much attention in the field of drug delivery. However, the progress is still limited by inefficient drug loading capacity of the conventional short ...

孙孟驰 Jin Sun 2018年第十二届中国药物制剂大会论文集 2018-11-30 中国会议

关键词: short / peptide / supramolecular / assembly

下载(2)| 被引(0)

Withanolides from Physalis genus and their biological ...  CNKI文献

The plants of Physcdis genus are distributed widely in the temperate and tropical zones of America.There are 5 species and 2 varieties in China,including P.alkekengi L.,P.alkekengi L.var.francheti,P....

Lixia Chen 第11届世界华人药物化学研讨会(ISCMC 2018)论文摘要集 2018-08-24 国际会议

关键词: Physalis / genus / withanolides / antitumor

下载(3)| 被引(0)

Carbazolyl oligomers:specific non-B DNA ligands and po...  CNKI文献

Targeting DNA is one of the strategies in the design of antitumor drugs.Specific DNA ligands may either possess excellent bio-activities or be used to explore biological functions of DNA,and therefor...

Peng Yang Gang Li... 第11届世界华人药物化学研讨会(ISCMC 2018)论文摘要集 2018-08-24 国际会议

关键词: Carbazole / Oligomer / DNA / Ligands

下载(0)| 被引(0)

Carrier-mediated Intestinal Absorption and Enterocytes...  CNKI文献

Decitabine(DAC),a potent DNA methyltransferase(DNMT) inhibitor,has a limited oral bioavailability.Its5'-amino acid ester prodrugs could lead to a favorable property for oral delivery but the spec...

Wenhui TAO Dongyang ZHAO... 2017年第十一届中国药物制剂大会暨中国药学会药剂专业委员会... 2017-10-27 国际会议

关键词: Decitabine / amino / acid / ester

下载(0)| 被引(0)

Redox-Responsive Prodrug Nanoassemblies for Cancer The...  CNKI文献

Tumor cells are characterized as redox-heterogeneous intracellular microenvironment due to the simultaneous overproduction of reactive oxygen species(ROS) and glutathione(GSH).In our previous study,s...

Jin Sun Bingju Sun... Proceedings of the 3rd International Conference on Nano... 2018-10-15 国际会议

关键词: DDS / Redox-Responsive / Prodrug / Nanoassemblies

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