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Immunostaining of PD-1/PD-Ls in liver tissues of patie...  CNKI文献

AIM: To investigate the expression of programmed death (PD)-1,PD ligand 1 (PD-L1) and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma (HCC).METHODS: Liver biop...

Michael Roggendorf 《World Journal of Gastroenterology》 2011年28期 期刊

关键词: Hepatitis / B / virus / Programmed

下载(115)| 被引(44)

RNAi induces innate immunity through multiple cellular...  CNKI文献

Background & Aims Our previous Conclusions showed that the knockdown of woodchuck hepatitis virus(WHV) by RNA interference(RNAi) led to upregulation of interferon stimulated genes(ISGs) in primar...

Zhongji Meng Xiaoyong Zhang... 中华医学会第十六次全国病毒性肝炎及肝病学术会议论文汇编 2013-06-20 中国会议

关键词: RNAi / induces / innate / immunity

下载(8)| 被引(0)

在土拨鼠原代肝细胞中Toll样受体抑制土拨鼠肝炎病毒复制(英...  CNKI文献

Toll like receptors (TLRs) play a critical role in activation of innate immune responses to infectious agents by recognition of pathogen associated molecular patterns.It has been shown that TLR agoni...

Jrg Schlaak Michael Roggendorf... 第七届全国病毒学学术研讨会暨第二届武汉现代病毒学国际研讨... 2007-10-01 国际会议

关键词: TLR / IFN / Toll

下载(9)| 被引(0)

Novel mouse models with a woodchuck hepatitis virus(WH...  CNKI文献

Background & Aims The woodchuck model is an informative model for studies on hepadnaviral infection. In this study,woodchuck hepatitis virus(WHV) transgenic(Tg) mouse models based on C57BL/6 mice...

Zhongji Meng Ejuan Zhang... 中华医学会第十六次全国病毒性肝炎及肝病学术会议论文汇编 2013-06-20 中国会议

关键词: WHV)transgene / show / sex-dependent / WHV

下载(3)| 被引(0)

Inhibition of the Woodchuck Hepatitis Virus gene expre...  CNKI文献

Small interfering RNA (siRNA) has been shown to be active to inhibit the hepatitis B virus gene expression and replication in transient and stable transfection systems. However,such systems differ fr...

Thomas Schreiter Michael Roggendorf... 第七届全国病毒学学术研讨会暨第二届武汉现代病毒学国际研讨... 2007-10-01 国际会议

关键词: siRNAs / Inhibition / of / the

下载(2)| 被引(0)

Regulation of Hepatitis C Virus Replication and Gene E...  CNKI文献

The mitogen activated protein kinases-extracellular signal regulated kinases (MAPK-ERK) pathway is involved in regulation of multiple cellular processes including the cell cycle. In the present study...

Michael Roggendorf 《Virologica Sinica》 2012年05期 期刊

关键词: Hepatitis / C / Virus / (HCV)

下载(42)| 被引(6)

HBV suppresses TLR-mediated innate immune responses in...  CNKI文献

Background and Aims:Recent studies suggest that HBV may suppress host defense by disabling TLR pathways.We have previously shown that non-parenchymal liver cells (NPC;Kupffer cells (KC),liver sinusoi...

Martin Trippler Ruth Broering... 第七届全国病毒学学术研讨会暨第二届武汉现代病毒学国际研讨... 2007-10-01 国际会议

关键词: HBV / suppresses / TLR-mediated / innate

下载(2)| 被引(0)

Development of Modified TiN Nanoparticles as Potential...  CNKI文献

One of the most promising emerging techniques for in vivo medical diagnostics is a Photoacoustic Tomography(PAT). This type of tomography is a non-ionizing and a non-invasive imaging modality, based ...

Ludmila Fadeev Michael Shur... Abstract Book of the 6th International Conference on Na... 2015-09-03 国际会议

关键词: Photoacoustic / Tomography / contrast / agents

下载(1)| 被引(0)

Advanced NDE Inspection Methods for Detection of SCC i...  CNKI文献

Power plant operators are often forced to make"release-repair-replace"decisions concerning components failed or reaching their designed life,thus reducing their availability.Possible failur...

Hans RAUSCHENBACH Michael CLOSSEN... Abstracts of 17th World Conference on Non-Destructive T... 2008-10-01 国际会议

关键词: Turbine / inspection / Phased / Array

下载(17)| 被引(0)

New therapeutic vaccination strategies for the treatme...  CNKI文献

Chronic hepatitis B virus(CHB) is currently treated with either interferon-based or nucleot(s)idebased antiviral therapies.However,treatment with pegylated interferon alpha results in a durable antiv...

Jia Liu Anna Kosinska... 《Virologica Sinica》 2014年01期 期刊

关键词: hepatitis / B / virus / woodchuck

下载(39)| 被引(11)

Interferon-α response in chronic hepatitis B-transfec...  CNKI文献

AIM: To characterize the IFN-response and its modul- ation by the antiviral compound lamivudine in HBV- transfected HepG2.2.15 cells. METHODS: HepG2.2.15 and HepG2 cells were stimulated with various ...

Petra Grnewald Michael Roggendorf... 《World Journal of Gastroenterology》 2007年02期 期刊

关键词: Hepatitis / B / IFN-a / Gene

下载(95)| 被引(30)

干扰素抗病毒蛋白MxA和2',5'-OAS在肝胚瘤细胞株中的差异表...  CNKI文献

目的了解α干扰素(interferon-α,IFN-α)诱导的抗病毒蛋白MxA和2',5'-寡腺苷酸合成酶(2',5'-OAS)在人肝胚瘤细胞株HepG2和HBV稳定转染的HepG2.2.15细胞中的表达情况。方法将培养的HepG2和HepG2.2.15...

管世鹤 杨东亮... 《中国感染与化疗杂志》 2006年03期 期刊

关键词: 肝炎病毒 / 乙型 / 干扰素 / 微矩阵

下载(240)| 被引(10)

TAILOR-MADE THERMOPLASTICS: PRODUCTION TECHNOLOGY AND ...  CNKI文献

The production of carbon fiber reinforced plastic(CFRP) parts for aircrafts is very time and cost intensive. To be able to compete with metal based technologies both the area of application as well a...

Matthias Beyrle RolAND Glück... 第二十一届国际复合材料大会论文集 专题七 2017-08-20 国际会议

关键词: Automated / preforming / Thermoplastics / CFRTP

下载(0)| 被引(0)

新型低密度cDNA Macroarray的建立及其应用于干扰素抗HBV的...  CNKI文献

目的了解人肝胚瘤细胞株HepG2和稳定转染HBV全基因组细胞株HepG2.2.15的干扰素(IFN)抗病毒基因表达谱。方法选择与IFN抗病毒及其信号转导途径相关的288个IMAGE克隆,经聚合酶链反应(PCR)扩增相应的基因片段,将扩增的DN...

管世鹤 刘华平... 《中华实验和临床病毒学杂志》 2005年03期 期刊

关键词: 肝炎病毒 / 乙型 / 干扰素类 / cDNAMacroarray技术

下载(102)| 被引(15)

Is it time for a Global Mining Initiative 2.0?  CNKI文献

From 1998-2002 the world's leading mining and metals companies developed the Global Mining Initiative(GMI) to understand their industry's role in the transition to sustainable development and...

Michael Tost Vighnesh Chandurkar... Proceedings of the 8th International Conference on Sust... 2017-06-26 国际会议

关键词: sustainable / development / sustainability / planetary

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Emergence of Differential Social License: A Case of Im...  CNKI文献

Impact and Benefit Agreements(IBAs) are intended to be a negotiated agreement between an industrial proponent and a community,local or regional citizens' organization.Although the elements have g...

Michael Hitch Michael Tost... Proceedings of the 8th International Conference on Sust... 2017-06-26 国际会议

关键词: impact / and / benefit / agreements

下载(0)| 被引(0)

VIRTUAL QUALIFICATION OF THE AIRCRAFT COMPUTER BASED O...  CNKI文献

This paper presents a reliability assessment approach for electronics using physics-of-failure(PoF) based virtual qualification. For this purpose, an aircraft computer, which is responsible for the a...

MICHAEL OSTERMAN MICHAEL PECHT Proceedings of the 4th International Conference on Qual... 2005-08-01 国际会议

关键词: Physics / of / Failure / Virtual

下载(33)| 被引(0)

Overview:A Simulation Based Metaheuristic Optimization...  CNKI文献

The implementation of intelligent power grids, in form of smart grids, introduces new challenges to the optimal dispatch of power. Thus, optimization problems need to be solved that become more and m...

Stephan Hutterer Franz Auinger... Final Program and Book of Abstracts of the 2010 Interna... 2010-09-17 国际会议

关键词: Simulation

下载(12)| 被引(0)

Online Velocity Trajectory Planning for Manual Energy ...  CNKI文献

This paper presents a novel approach to online velocity trajectory planning for manual energy efficient driving which involves Model Predictive Control(MPC) for map-based anticipatory driving of heav...

Michael Henzler Michael Buchholz... Proceedings of 17th International IEEE Conference on In... 2014-10-08 国际会议

关键词: MPC / Online / Velocity / Trajectory

下载(6)| 被引(0)

A Method of Reliability Assessment on Creep Corrosion ...  CNKI文献

This study focuses on a method of reliability assessment for creep corrosion on immersion silver-finished PCBs utilizing the mixed flow gas(MFG)test and clay test.Four kinds of locations were defined...

Anshul Shrivastava Michael Osterman... The Proceedings of 2009 8th International Conference on... 2009-07-20 国际会议

关键词: mixed / flow / gas(MFG) / clay

下载(14)| 被引(0)

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